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| Research Progress of Quorum Sensing System in Regulating Klebsiella pneumoniae Biofilm Formation |
| WANG Yiming1，2，TAN Zining1，2，ZHU Daomi1，2，CHEN Linlin1，2，MA Hongxia1，2，3** |
| WANG Yiming1，2，TAN Zining1，2，ZHU Daomi1，2，CHEN Linlin1，2，MA Hongxia1，2，3** |
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Abstract Biofilm (BF) is a sessile microbial community formed when bacteria adhere to solid sur?
faces, of which the released extracellular polymers can improve resistance to antibiotics and host im?
mune system. Recently, with the ever deepening understanding of pathogenesis and development and
usage of novel antibacterial agents, infectious diseases have been controlled efficiently. However,
high drug selection pressure has resulted in frequent appearance of drug-resistant strains, posing a
serious threat to human and animal health. Klebsiella pneumoniae is a common opportunistic bacte?rium, and the formation of its biofilm is closely related to bacterial virulence and drug resistance.
Studies found that bacterial quorum sensing (QS) system plays a key role in BF formation. BF forma?
tion can be effectively prevented by inhibiting QS system, and thus reducing pathogen virulence and
drug resistance. As a result, inhibiting QS related molecules could be a novel strategy against BF for?
mation, with vital clinical significance. The article reviewed Klebsiella pneumoniae BF formation, QS system and its regulation effect on BF, as well as the effective routes to suppress QS system, aiming to provide new ideas for relative research on QS regulation of BF.
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Received: 03 September 2022
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